Publications

2024

Chen A, Lupan AM, Quek RT, Stanciu SG, Asaftei M, Stanciu GA, Hardy KS, de Almeida Magalhães T, Silver PA, Mitchison TJ, Salic A. A coronaviral pore-replicase complex links RNA synthesis and export from double-membrane vesicles. Sci Adv. 2024 Nov 8;10(45):eadq9580. doi: 10.1126/sciadv.adq9580. Epub 2024 Nov 8. PMID: 39514670; PMCID: PMC11546809.

Fang R, Bai L, Li B, Dong K, Paulo JA, Zhou M, Chu YC, Song Y, Sherman MY, Gygi S, Field CM, Mitchison TJ, Lu Y. Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation. bioRxiv [Preprint]. 2024 Aug 7:2024.08.06.606767. doi: 10.1101/2024.08.06.606767. PMID: 39211171; PMCID: PMC11361152.

Yoo TY, Mitchison TJ. Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2307997121. doi: 10.1073/pnas.2307997121. Epub 2024 Jan 18. PMID: 38236733; PMCID: PMC10823255.

2023

Quek RT, Hardy KS, Walker SG, Nguyen DT, de Almeida Magalhães T, Salic A, Gopalakrishnan SM, Silver PA, Mitchison TJ. Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity. ACS Chem Biol. 2023 Mar 17;18(3):583-594. doi: 10.1021/acschembio.2c00908. Epub 2023 Feb 16. PMID: 36795767.

2022

Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Dev Biol. 2023 Jan;493:67-79. doi: 10.1016/j.ydbio.2022.10.013. Epub 2022 Nov 2. PMID: 36334838; PMCID: PMC10194025.

Bai L, Mitchison TJ. Spring-like behavior of cytoplasm holds the mitotic spindle in place. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2203036119. doi: 10.1073/pnas.2203036119. Epub 2022 Mar 24. PMID: 35324318; PMCID: PMC9169080.

Ng TL, Olson EJ, Yoo TY, Weiss HS, Koide Y, Koch PD, Rollins NJ, Mach P, Meisinger T, Bricken T, Chang TZ, Molloy C, Zürcher J, Chang RL, Mitchison TJ, Glass JI, Marks DS, Way JC, Silver PA. High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response. mSystems. 2022 Apr 26;7(2):e0146621. doi: 10.1128/msystems.01466-21. Epub 2022 Mar 23. PMID: 35319251; PMCID: PMC9040872.

2021

Munjal A, Hannezo E, Tsai TY, Mitchison TJ, Megason SG. Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. Cell. 2021 Dec 22;184(26):6313-6325.e18. doi: 10.1016/j.cell.2021.11.025. PMID: 34942099; PMCID: PMC8722442.

Flynn PJ, Koch PD, Mitchison TJ. Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2103585118. doi: 10.1073/pnas.2103585118. PMID: 34819364; PMCID: PMC8640936.

Shi J, Weng JH, Mitchison TJ. Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses. Elife. 2021 Nov 15;10:e73673. doi: 10.7554/eLife.73673. PMID: 34779403; PMCID: PMC8592567.

Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10. doi: 10.1016/j.ccell.2021.06.018. Epub 2021 Jul 22. PMID: 34375612.

Mitchison TJ. So many ways to naturally kill a cancer cell. BMC Biol. 2021 Jul 30;19(1):149. doi: 10.1186/s12915-021-01092-3. PMID: 34325682; PMCID: PMC8323262.

Mitchison TJ, Field CM. Self-Organization of Cellular Units. Annu Rev Cell Dev Biol. 2021 Oct 6;37:23-41. doi: 10.1146/annurev-cellbio-120319-025356. Epub 2021 Jun 29. PMID: 34186005; PMCID: PMC9059766.

Weng JH, Koch PD, Luan HH, Tu HC, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison TJ. Publisher Correction: Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021 May;3(5):728. doi: 10.1038/s42255-021-00397-5. Erratum for: Nat Metab. 2021 Apr;3(4):513-522. doi: 10.1038/s42255-021-00366-y. PMID: 33953392.

Weng JH, Koch PD, Luan HH, Tu HC, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison TJ. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021 Apr;3(4):513-522. doi: 10.1038/s42255-021-00366-y. Epub 2021 Apr 12. Erratum in: Nat Metab. 2021 May;3(5):728. doi: 10.1038/s42255-021-00397-5. PMID: 33846641; PMCID: PMC8175070.

Shimada K, Bachman JA, Muhlich JL, Mitchison TJ. shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data. Elife. 2021 Feb 8;10:e57116. doi: 10.7554/eLife.57116. PMID: 33554860; PMCID: PMC7924953.

Ishihara K, Decker F, Caldas P, Pelletier JF, Loose M, Brugués J, Mitchison TJ. Spatial variation of microtubule depolymerization in large asters. Mol Biol Cell. 2021 Apr 19;32(9):869-879. doi: 10.1091/mbc.E20-11-0723. Epub 2021 Jan 13. PMID: 33439671; PMCID: PMC8108532.

2020

Mitchison TJ. Cell Biology: Size Scaling of Mitotic Spindles. Curr Biol. 2020 Dec 21;30(24):R1476-R1478. doi: 10.1016/j.cub.2020.09.047. PMID: 33352128; PMCID: PMC8108444.

Pelletier JF, Field CM, Fürthauer S, Sonnett M, Mitchison TJ. Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife. 2020 Dec 7;9:e60047. doi: 10.7554/eLife.60047. PMID: 33284105; PMCID: PMC7759381.

Mitchison TJ. Shinya Inoué (1921-2019). Cell. 2020 Jan 9;180(1):2-5. doi: 10.1016/j.cell.2019.12.022. Epub 2020 Jan 9. PMID: 33238108.

Mitchison TJ. Beyond Langmuir: surface-bound macromolecule condensates. Mol Biol Cell. 2020 Nov 1;31(23):2502-2508. doi: 10.1091/mbc.E20-06-0393. PMID: 33119461; PMCID: PMC7851878.

Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020 Jul 14;11(1):3521. doi: 10.1038/s41467-020-17147-y. PMID: 32665556; PMCID: PMC7360550.

Geisterfer ZM, Zhu DY, Mitchison TJ, Oakey J, Gatlin JC. Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density. Curr Biol. 2020 Aug 3;30(15):3016-3023.e3. doi: 10.1016/j.cub.2020.05.056. Epub 2020 Jun 11. PMID: 32531285; PMCID: PMC7416492.

Gasic I, Groendyke BJ, Nowak RP, Yuan JC, Kalabathula J, Fischer ES, Gray NS, Mitchison TJ. Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells. 2020 Apr 27;9(5):1083. doi: 10.3390/cells9051083. PMID: 32349222; PMCID: PMC7290497.

Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, Hegde RS. TTC5 mediates autoregulation of tubulin via mRNA degradation. Science. 2020 Jan 3;367(6473):100-104. doi: 10.1126/science.aaz4352. Epub 2019 Nov 14. PMID: 31727855; PMCID: PMC69425410

2019

Florian S, Mitchison TJ. Crowds and power - coordinated in vitro development of a benign breast lesion. Mol Cell Oncol. 2019 Aug 26;6(6):e1648739. doi: 10.1080/23723556.2019.1648739. PMID: 31692941; PMCID: PMC6816444.

Mitchison TJ, Field CM. Toward synthetic cells. Science. 2019 Nov 1;366(6465):569-570. doi: 10.1126/science.aaz5635. PMID: 31672880.

Field CM, Pelletier JF, Mitchison TJ. Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs. Curr Biol. 2019 Jun 17;29(12):1999-2008.e4. doi: 10.1016/j.cub.2019.05.016. Epub 2019 Jun 6. PMID: 31178324; PMCID: PMC6639026.

Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ. A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11444-11453. doi: 10.1073/pnas.1702372116. Epub 2019 May 17. PMID: 31101720; PMCID: PMC6561274.

Gasic I, Boswell SA, Mitchison TJ. Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues. PLoS Biol. 2019 Apr 9;17(4):e3000225. doi: 10.1371/journal.pbio.3000225. PMID: 30964857; PMCID: PMC6474637.

Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457. doi: 10.7554/eLife.45457. PMID: 30907729; PMCID: PMC6450673.

Shimada K, Mitchison TJ. Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles. Mol Syst Biol. 2019 Feb 19;15(2):e8636. doi: 10.15252/msb.20188636. PMID: 30782979; PMCID: PMC6380462.

Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK. A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Sci Data. 2019 Feb 19;6:190016. doi: 10.1038/sdata.2019.16. PMID: 30778261; PMCID: PMC6380223.

Nguyen T, Mitchison TJ, Wühr M. Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos. Methods Mol Biol. 2019;1920:17-32. doi: 10.1007/978-1-4939-9009-2_2. PMID: 30737683; PMCID: PMC6582944.

Mitchison TJ. Colloid osmotic parameterization and measurement of subcellular crowding. Mol Biol Cell. 2019 Jan 15;30(2):173-180. doi: 10.1091/mbc.E18-09-0549. PMID: 30640588; PMCID: PMC6589563.

2018

Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ. Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11406-E11414. doi: 10.1073/pnas.1800047115. Epub 2018 Nov 14. PMID: 30429313; PMCID: PMC6275538.

Gasic I, Mitchison TJ. Autoregulation and repair in microtubule homeostasis. Curr Opin Cell Biol. 2019 Feb;56:80-87. doi: 10.1016/j.ceb.2018.10.003. Epub 2018 Nov 8. PMID: 30415186.

Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 Aug 6;9(1):3116. doi: 10.1038/s41467-018-05036-4. PMID: 30082792; PMCID: PMC6078993.

Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018 May 1;27(5):1067-1080.e5. doi: 10.1016/j.cmet.2018.03.018. PMID: 29685734; PMCID: PMC5932087.

Wang Y, Li YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ. Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 2018 Mar 12;7:e36414. doi: 10.7554/eLife.36414. Erratum for: Elife. 2014 May 20;3:e01763. doi: 10.7554/eLife.01763. PMID: 29528283; PMCID: PMC5847332.

Field CM, Mitchison TJ. Assembly of Spindles and Asters in Xenopus Egg Extracts. Cold Spring Harb Protoc. 2018 Jun 1;2018(6):pdb.prot099796. doi: 10.1101/pdb.prot099796. PMID: 29437996; PMCID: PMC5984692.

Mitchison TJ, Field CM. Spindle-to-Cortex Communication in Cleaving Frog Eggs. Cold Spring Harb Symp Quant Biol. 2017;82:165-171. doi: 10.1101/sqb.2017.82.033654. Epub 2017 Dec 1. PMID: 29196560; PMCID: PMC5984124.

Nguyen PA, Field CM, Mitchison TJ. Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters. Mol Biol Cell. 2018 Feb 1;29(3):304-316. doi: 10.1091/mbc.E17-09-0540. Epub 2017 Nov 29. PMID: 29187577; PMCID: PMC5996955.

2017

Mitchison TJ, Pineda J, Shi J, Florian S. Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug? Open Biol. 2017 Nov;7(11):170182. doi: 10.1098/rsob.170182. PMID: 29142107; PMCID: PMC5717346.

Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. Correction: 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 2017 May 4;6:e28212. doi: 10.7554/eLife.28212. Erratum for: Elife. 2017 Feb 28;6:e22911. doi: 10.7554/eLife.22911. PMID: 28470149; PMCID: PMC5417848.

Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 7;28(14):1975-1983. doi: 10.1091/mbc.E17-03-0171. Epub 2017 May 3. PMID: 28468979; PMCID: PMC5541847.

Costigliola N, Ding L, Burckhardt CJ, Han SJ, Gutierrez E, Mota A, Groisman A, Mitchison TJ, Danuser G. Vimentin fibers orient traction stress. Proc Natl Acad Sci U S A. 2017 May 16;114(20):5195-5200. doi: 10.1073/pnas.1614610114. Epub 2017 May 2. PMID: 28465431; PMCID: PMC5441818.

Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ. Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin. Mol Biol Cell. 2017 Jun 1;28(11):1444-1456. doi: 10.1091/mbc.E16-12-0860. Epub 2017 Apr 12. PMID: 28404751; PMCID: PMC5449145.

Shi J, Mitchison TJ. Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic. Endocr Relat Cancer. 2017 Sep;24(9):T83-T96. doi: 10.1530/ERC-17-0003. Epub 2017 Mar 1. PMID: 28249963; PMCID: PMC5557680.

Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 2017 Feb 28;6:e22911. doi: 10.7554/eLife.22911. Erratum in: Elife. 2017 May 04;6:e28212. doi: 10.7554/eLife.28212. PMID: 28244368; PMCID: PMC5370190.

Field CM, Pelletier JF, Mitchison TJ. Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis. Methods Cell Biol. 2017;137:395-435. doi: 10.1016/bs.mcb.2016.04.014. Epub 2016 May 9. PMID: 28065319; PMCID: PMC5322469.

Boke E, Mitchison TJ. The balbiani body and the concept of physiological amyloids. Cell Cycle. 2017 Jan 17;16(2):153-154. doi: 10.1080/15384101.2016.1241605. Epub 2016 Oct 13. PMID: 27736303; PMCID: PMC5283817.

2016

Ishihara K, Korolev KS, Mitchison TJ. Physical basis of large microtubule aster growth. Elife. 2016 Nov 28;5:e19145. doi: 10.7554/eLife.19145. PMID: 27892852; PMCID: PMC5207775.

Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R. Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep. 2016 Sep 9;6:32985. doi: 10.1038/srep32985. PMID: 27609668; PMCID: PMC5017129.

Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9810-5. doi: 10.1073/pnas.1606862113. Epub 2016 Aug 15. PMID: 27528663; PMCID: PMC5024598.

Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ. Amyloid-like Self-Assembly of a Cellular Compartment. Cell. 2016 Jul 28;166(3):637-650. doi: 10.1016/j.cell.2016.06.051. PMID: 27471966; PMCID: PMC5082712.

Florian S, Mitchison TJ. Anti-Microtubule Drugs. Methods Mol Biol. 2016;1413:403-21. doi: 10.1007/978-1-4939-3542-0_25. PMID: 27193863.

Groen AC, Mitchison TJ. Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts. Methods Mol Biol. 2016;1413:35-45. doi: 10.1007/978-1-4939-3542-0_3. PMID: 27193841.

Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU. Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. ACS Chem Biol. 2016 Jun 17;11(6):1544-51. doi: 10.1021/acschembio.6b00203. Epub 2016 Apr 28. PMID: 27121275; PMCID: PMC4990065.

2015

Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis. J Cell Biol. 2015 Nov 23;211(4):757-63. doi: 10.1083/jcb.201505058. PMID: 26598613; PMCID: PMC4657169.

Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP. The Nuclear Proteome of a Vertebrate. Curr Biol. 2015 Oct 19;25(20):2663-71. doi: 10.1016/j.cub.2015.08.047. Epub 2015 Oct 1. PMID: 26441354; PMCID: PMC4618192.

Field CM, Groen AC, Nguyen PA, Mitchison TJ. Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs. Mol Biol Cell. 2015 Oct 15;26(20):3628-40. doi: 10.1091/mbc.E15-04-0233. Epub 2015 Aug 26. PMID: 26310438; PMCID: PMC4603933.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741c. Erratum for: Nat Chem Biol. 2014 Dec;10(12):1043-8. doi: 10.1038/nchembio.1661. PMID: 26284675.

Mitchison TJ, Ishihara K, Nguyen P, Wühr M. Size Scaling of Microtubule Assemblies in Early Xenopus Embryos. Cold Spring Harb Perspect Biol. 2015 Aug 10;7(10):a019182. doi: 10.1101/cshperspect.a019182. PMID: 26261283; PMCID: PMC4588060.

Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ. In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015 Jun;12(6):577-85. doi: 10.1038/nmeth.3363. Epub 2015 Apr 13. PMID: 25867850; PMCID: PMC4579269.

Krukenberg KA, Kim S, Tan ES, Maliga Z, Mitchison TJ. Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages. Chem Biol. 2015 Apr 23;22(4):446-452. doi: 10.1016/j.chembiol.2015.03.007. Epub 2015 Apr 9. PMID: 25865309; PMCID: PMC4409933.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2015 Mar;11(3):235. doi: 10.1038/nchembio0315-235d. Erratum for: Nat Chem Biol. 2014 Dec;10(12):1043-8. doi: 10.1038/nchembio.1661. PMID: 25689338.

Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA. Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis. EMBO J. 2015 Jan 13;34(2):251-65. doi: 10.15252/embj.201385162. Epub 2014 Dec 4. PMID: 25476450; PMCID: PMC4337065.

Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M. Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins. Methods Cell Biol. 2015;128:223-241. doi: 10.1016/bs.mcb.2015.01.007. Epub 2015 Apr 8. PMID: 25997350; PMCID: PMC4578691.

2014

Nguyen PA, Groen AC, Field CM, Mitchison TJ. Microtubule nucleation remote from centrosomes may explain how asters span large cells. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17715-22. doi: 10.1073/pnas.1418796111. Epub 2014 Dec 2. PMID: 25468969; PMCID: PMC4273342.

Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2014 Dec;10(12):1043-8. doi: 10.1038/nchembio.1661. Epub 2014 Oct 26. Erratum in: Nat Chem Biol. 2015 Mar;11(3):235. doi: 10.1038/nchembio0315-235d. Erratum in: Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741c. PMID: 25344812; PMCID: PMC4232468.

Choi PJ, Mitchison TJ. Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics. Integr Biol (Camb). 2014 Dec;6(12):1153-61. doi: 10.1039/c4ib00096j. Epub 2014 Sep 17. PMID: 25228316.

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 5;6(261):261ra152. doi: 10.1126/scitranslmed.3009318. PMID: 25378644; PMCID: PMC4330962.

Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ. Spatial organization of cytokinesis signaling reconstituted in a cell-free system. Science. 2014 Oct 10;346(6206):244-7. doi: 10.1126/science.1256773. PMID: 25301629; PMCID: PMC4281018.

Krukenberg KA, Jiang R, Steen JA, Mitchison TJ. Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. Cell Rep. 2014 Sep 25;8(6):1808-1818. doi: 10.1016/j.celrep.2014.08.009. Epub 2014 Sep 4. PMID: 25199834; PMCID: PMC4177365.

Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ. Organization of early frog embryos by chemical waves emanating from centrosomes. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650):20130454. doi: 10.1098/rstb.2013.0454. PMID: 25047608; PMCID: PMC4113098.

Mitchison TJ. The engine of microtubule dynamics comes into focus. Cell. 2014 May 22;157(5):1008-10. doi: 10.1016/j.cell.2014.05.001. PMID: 24855939.

Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 2014 May 20;3:e01763. doi: 10.7554/eLife.01763. Erratum in: Elife. 2018 Mar 12;7:e36414. doi: 10.7554/eLife.36414. PMID: 24844244; PMCID: PMC4059381.

Groen AC, Ngyuen PA, Field CM, Ishihara K, Mitchison TJ. Glycogen-supplemented mitotic cytosol for analyzing Xenopus egg microtubule organization. Methods Enzymol. 2014;540:417-33. doi: 10.1016/B978-0-12-397924-7.00023-6. PMID: 24630120.

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